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  • Title: [The adaptation of an isolate of the hepatitis A virus to reproduction in cell cultures].
    Author: Farashian VR, Bychenko AB, Kuzaeva IA, Artemov EK, Kadoshnikov IuP.
    Journal: Vopr Virusol; 1991; 36(2):117-9. PubMed ID: 1652866.
    Abstract:
    A HAV strain derived from a patient in Moscow multiplied in a continuous cell line PLC/PRF/5 at 32 degrees C (variant MI-1) and at 37 degrees C (variant MI-1.1). These two variants of the strain MI retained the ability for reproduction both at 32 degrees C and 37 degrees C after passages in cell culture. The strain MI also replicates in MK cells. Negative results on HAV cultivation were obtained in HEF-240 and FRhK-4 cell cultures. The MI-1 and MI-1.1 variants are typical of hepatitis A viruses by their physicochemical properties, the results of ELISA, protein electrophoresis and dot hybridization tests.
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