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  • Title: Detection of hepatitis C viral RNA in serum of a patient with acute non A, non B hepatitis.
    Author: Waxman I, Baker B, Feinstone SM, Di Bisceglie AM.
    Journal: Am J Gastroenterol; 1991 Sep; 86(9):1240-2. PubMed ID: 1652887.
    Abstract:
    The sequence of serologic events in a patient with acute type C hepatitis associated with intravenous drug abuse is described. Hepatitis C virus (HCV) ribonucleic acid was detectable in serum during the acute episode of hepatitis, whereas antibody to the hepatitis C virus appeared later, after the acute illness had subsided. The patient developed chronic hepatitis with persistently elevated serum aminotransferase activities. Both hepatitis C viral ribonucleic acid and antibody to hepatitis C virus persisted in serum, together with elevated serum aminotransferases. Thus, detection of HCV RNA may be useful in the diagnosis of acute type C hepatitis, particularly in the absence of detectable antibody to the hepatitis C virus.
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