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  • Title: Dictyostelium discoideum chemotaxis: threshold for directed motion.
    Author: Song L, Nadkarni SM, Bödeker HU, Beta C, Bae A, Franck C, Rappel WJ, Loomis WF, Bodenschatz E.
    Journal: Eur J Cell Biol; 2006 Sep; 85(9-10):981-9. PubMed ID: 16529846.
    Abstract:
    The chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3',5'-monophosphate (cAMP) was studied using microfluidic devices. In shallow gradients of less than 10(-3) nM/microm, the cells showed no directional response and exhibited a constant basal motility. In steeper gradients, cells moved up the gradient on average. The chemotactic speed and the motility increased with increasing steepness up to a plateau at around 10(-1) nM/microm. In very steep gradients, above 10 nM/microm, the cells lost directionality and the motility returned to the sub-threshold level. In the regime of optimal response the difference in receptor occupancy at the front and back of the cell is estimated to be only about 100 molecules.
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