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  • Title: Efficacy of inactivated trivalent influenza vaccine in alleviating the febrile illness of culture-confirmed influenza in children in the 2000-2001 influenza season.
    Author: Kamada M, Nagai T, Kumagai T, Igarashi M, Ihara T, Okafuji T, Ochiai H, Sakiyama H, Shimomura K, Suzuki E, Torigoe S, Miyazaki C, Miyata A, Yuri K, Ito Y, Nakayama T, Kase T, Okuno Y.
    Journal: Vaccine; 2006 Apr 24; 24(17):3618-23. PubMed ID: 16530300.
    Abstract:
    During the 2000/2001 influenza season in Japan, children ranging in age from 6 months to 13 years with fever exceeding 37.5 degrees C were recruited. Vaccine efficacy was evaluated by comparing the rates of pre-seasonal vaccination between groups stratified by fever severity. Seven hundred and sixty one patients (33.1%), culture positive for influenza were enrolled for analysis. The numbers of patients for A/H1N1 and A/H3N2 were insufficient for statistical analysis. For influenza B the odds ratio for vaccinated children to have a maximum fever exceeding 39.5 degrees C was 0.52 (95% CI, 0.30-0.92) Our findings suggest modest impact of influenza vaccination on limiting severity of disease symptoms.
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