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Title: Drug therapy of trigeminal neuralgia. Author: Canavero S, Bonicalzi V. Journal: Expert Rev Neurother; 2006 Mar; 6(3):429-40. PubMed ID: 16533146. Abstract: Trigeminal neuralgia is a chronic pain syndrome of still unestablished origin. Its diagnosis depends on clinical grounds. Drug therapy initially helps a great majority of patients. The choice of drugs is quite large, but truly effective compounds with a tolerable side effect profile remain few. Carbamazepine (or oxcarbazepine) and lamotrigine appear to be the most effective, followed by baclofen. Several patients require further nonpharmacological treatment for which no evidence-based recommendation is possible. In the future, neuromodulation may be brought to bear, as in other chronic pain syndromes.[Abstract] [Full Text] [Related] [New Search]