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  • Title: Single-nucleotide polymorphism identification in the caprine myostatin gene.
    Author: Li XL, Wu ZhL, Gong YF, Liu YQ, Liu ZZ, Wang XJ, Xin TR, Ji Q.
    Journal: J Anim Breed Genet; 2006 Apr; 123(2):141-4. PubMed ID: 16533369.
    Abstract:
    Polymerase chain reaction (PCR) products of MSTN gene amplified from 35 goats representing 17 Chinese indigenous goat breeds and five imported goat breeds were sequenced to identify the single-nucleotide polymorphisms (SNPs) of a 379-bp fragment including part of intron 2 and exon 3 of MSTN gene. A total of eight SNPs (A1980G, G1981C, A1982G, G1984T, A2121G, T2124C, G2174A and A2246G) were identified among the sequenced goats. The SNPs found are all located in intron 2 except for A2246G, which was a synonymous mutation in exon 3. Four haplotypes were sorted from these eight SNPs, of which, haplotype I (AGAGATGA) and haplotype II (GCGTGTAA) are the two main haplotypes with the frequency of 77.8% and 14.8% respectively. The SNPs found at positions 1980, 1981, 1982, 1984 and 2121 might be linked to inheritance completely.
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