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  • Title: [The mechanism of Na+--K+ pump dysfunction in the erythrocytes of patients with glomerulonephritis and kidney failure].
    Author: Ponomarenko ED, Lazovskis IR, Pletneva TP, Maslova MN.
    Journal: Ter Arkh; 1991; 63(5):105-9. PubMed ID: 1653466.
    Abstract:
    The mechanisms of Na, K-ATPase dysfunction in red blood cells of patients suffering from glomerulonephritis and renal failure were studied by means of "functional loads" of an enzyme, enabling not only the activity but also the routine of Na, K-ATPase to be determined. Evidence is provided for the presence of immunotoxic factor on the patients' red blood cells, in the plasma of venous blood and serum of arterial blood. Its excretion from the patients' body and recovery of the routine of Na, K-ATPase have been simulated in vivo and in vitro. The cold immunoglobulin nature of the inhibitor related to the M-chains of IgM was established. It has been shown that the mechanisms of formation of the immunopathogenesis of glomerulonephritis are associated with the appearance of cold autoantibodies and their fragments on blood cell membranes, bringing about a decrease of the activity of Na, K-ATPase and modifying its routine.
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