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  • Title: Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women.
    Author: Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I.
    Journal: Cancer Epidemiol Biomarkers Prev; 2006 Mar; 15(3):443-8. PubMed ID: 16537699.
    Abstract:
    BACKGROUND: High intake of folate, vitamin B(6), and vitamin B(12) have been hypothesized to lower the risk for breast cancer. We conducted a population-based case-control study to evaluate the risk for breast cancer among Mexican women with relatively low vitamin intakes. METHODS: We included 475 women (median age, 53 years; range, 23-87 years) diagnosed with incident breast cancer through six hospitals in Mexico City and interviewed them to obtain data on breast cancer risk factors and their usual diet using a food frequency questionnaire. We selected 1,391 (median age, 49 years; range, 18-82 years) controls from the Mexico City population using a national sampling frame. RESULTS: Compared with women in the lowest quartile, the odds ratio for breast cancer for women in the highest quartile of folate intake was 0.64 [95% confidence intervals (CI), 0.45-0.90; P, test for trend = 0.009] and 0.32 (95% CI, 0.22-0.49; P, test for trend < 0.0001) for vitamin B(12) intake. Among postmenopausal women, intakes of folate and vitamin B(12) were associated with a lower risk of breast cancer and those associations were stronger than among premenopausal women. The inverse association of folate and breast cancer was stronger among women who consumed a high level of vitamin B(12) as compared with women consuming diets low in vitamin B(12). No association was observed for vitamin B(6) intake. CONCLUSIONS: In this population, high intakes of folate and vitamin B(12) were independently associated with decreased breast cancer risk, particularly among postmenopausal women.
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