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  • Title: The role of mannose in the receptor of the monocyte locomotion inhibitory factor produced by Entamoeba histolytica.
    Author: Kretschmer RR, Castro EM, Pacheco G, Rico G, Díaz-Guerra O, Arellano J.
    Journal: Parasitol Res; 1991; 77(5):374-8. PubMed ID: 1653955.
    Abstract:
    The effect of the monocyte locomotion inhibitory factor (MLIF) produced by Entamoeba histolytica is diminished, if not cancelled, when human monocytes are pre-exposed to concanavalin A or sodium periodate, respectively, but not when MLIF is pretreated with sodium periodate. When the MLIF-inhibited monocyte locomotion assays were performed in the presence of 12 different carbohydrates, only the runs containing D-mannose, 4-O-beta-galactosyl-mannoside or mannan revealed a significant reduction in the inhibitory effect. Finally, the MLIF activity was virtually absorbed out with mannan-coupled Sepharose 4B beads. This suggests that D-mannose constitutes an essential part of the receptor for MLIF on the human monocyte membrane.
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