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  • Title: Amygdala or hippocampus inactivation after retrieval induces temporary memory deficit.
    Author: Prado-Alcalá RA, Díaz del Guante MA, Garín-Aguilar ME, Díaz-Trujillo A, Quirarte GL, McGaugh JL.
    Journal: Neurobiol Learn Mem; 2006 Sep; 86(2):144-9. PubMed ID: 16540353.
    Abstract:
    The hypothesis that memory is stored through a single stage of consolidation that results in a stable and lasting long-term memory has been challenged by the proposition that reactivation of a memory induces reconsolidation of the memory. The reconsolidation hypothesis is supported by evidence that, under some conditions, post-retrieval treatments affecting amygdala and hippocampus functioning impair subsequent retention performance. We now report that repeated retention testing attenuates the performance impairment induced by post-retrieval reversible inactivation of the amygdala and hippocampus of rats induced by tetrodotoxin. These findings challenge the reconsolidation hypothesis and suggest that the post-retrieval retention performance impairment is best explained as due to temporary retrieval failure.
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