These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: New insights into the pathophysiology of the small airways in asthma.
    Author: Tulic MK, Hamid Q.
    Journal: Clin Chest Med; 2006 Mar; 27(1):41-52, vi. PubMed ID: 16543051.
    Abstract:
    Airway inflammation and remodeling in asthma occur in the central airways and also in the small airways and in the lung parenchyma. The small airways and the lung parenchyma can produce many Th2 cytokines, chemokines, and mediators involved in initiation and perpetuation of the inflammatory process. The distal lung has been recognized as a predominant site of airflow obstruction in asthmatics. Distal inflammation has been described as more severe than large airway inflammation, and strong evidence of remodeling in the lung periphery is emerging. Recognition of asthma as a disease of the entire respiratory tract has clinical significance, highlighting the need to target the distal lung in any strategy for effective treatment of this disease.
    [Abstract] [Full Text] [Related] [New Search]