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  • Title: Influence of heat stimulation on the amount of calcitonin gene-related peptide and neurokinin A in the subcutaneous space of the rat hind instep.
    Author: Yonehara N, Imai Y, Inoki R.
    Journal: Jpn J Pharmacol; 1991 Jul; 56(3):381-4. PubMed ID: 1654475.
    Abstract:
    The release of tachykinins and calcitonin gene-related peptide (CGRP) into subcutaneous perfusates was investigated. Immersion of the hind paw of rats in water at 47 degrees C for 30 min led to a marked increase of immunoreactive CGRP (iCGRP) release as well as immunoreactive substance P release, but no detectable increase of immunoreactive neurokinin A release. Neonatal pretreatment with capsaicin or section of the sciatic and the saphenous nerves significantly inhibited the heat stimulation-induced release of iCGRP.
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