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  • Title: The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
    Author: Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T.
    Journal: FEBS Lett; 2006 Apr 03; 580(8):2011-4. PubMed ID: 16545378.
    Abstract:
    Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by selectively cleaving core components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin-I and -II act as receptors for BoNT/B and BoNT/G. Here we show that BoNT/A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A and SV2B. Binding of BoNT/A occurs at the membrane juxtaposed region preceding transmembrane domain 8. A peptide comprising the intravesicular domain between transmembrane domains 7 and 8 specifically reduces the neurotoxicity of BoNT/A at phrenic nerve preparations demonstrating the physiological relevance of this interaction.
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