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  • Title: Toxoplasma gondii: immunogenicity and protection by P30 peptides in a murine model.
    Author: Siachoque H, Guzman F, Burgos J, Patarroyo ME, Gomez Marin JE.
    Journal: Exp Parasitol; 2006 Sep; 114(1):62-5. PubMed ID: 16545806.
    Abstract:
    Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge.
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