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  • Title: Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
    Author: Chen J, Liu J, Zhang L, Wu G, Hua W, Wu X, Sun H.
    Journal: Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2915-9. PubMed ID: 16546381.
    Abstract:
    Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 microM) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed.
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