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Title: Hepatic effects of influxed endothelin-1 from portal vein: in situ portal vein infusion model using dogs. Author: Kuroda N, Yamanaka J, Okada T, Hirano T, Iimuro Y, Fujimoto J. Journal: J Hepatobiliary Pancreat Surg; 2006; 13(2):160-6. PubMed ID: 16547679. Abstract: BACKGROUND/PURPOSE: Endothelin-1 is a potent vasoconstrictor formed by vascular endothelium. This study was designed to investigate the hepatic effect of endothelin-1 produced by portal vascular endothelium. METHODS: Portal venous pressure, portal venous flow, hepatic arterial flow, tissue blood flow, and tissue oxygen pressure were measured during portal vein endothelin-1 infusion in dogs at rates of 1.0 to 5.0 ng/kg per minute. Sinusoidal width during maximal infusion was determined morphometrically. Serum concentrations of mitochondrial glutamic oxaloacetic transaminase and endothelin-1 in portal and hepatic venous blood were also measured. RESULTS: Intraportal endothelin-1 infusion dose-dependently increased portal venous pressure and reduced portal venous and hepatic arterial blood flow. Tissue blood flow and oxygen pressure also decreased. Endothelin-1 also significantly increased serum mitochondrial glutamic oxaloacetic transaminase and constricted hepatic sinusoids. These changes reversed after completion of infusion. CONCLUSIONS: Intraportal endothelin-1 caused circulatory and histological changes in hepatic sinusoids that may suggest the role of endothelin-1 formed by portal venous bed epithelium.[Abstract] [Full Text] [Related] [New Search]