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  • Title: Successful reduced intensity allogeneic stem cell transplantation for systemic AL amyloidosis.
    Author: Imamura T, Ogata M, Kohno K, Tomo T, Ohtsuka E, Kikuchi H, Kadota J.
    Journal: Am J Hematol; 2006 Apr; 81(4):281-3. PubMed ID: 16550508.
    Abstract:
    No established treatments for systemic AL amyloidosis have been determined, and only four reports have described allogeneic stem cell transplantation for this disease. We report the case of a patient with orthostatic hypotension, diarrhea, nephrotic syndrome, and cardiac amyloidosis due to systemic AL amyloidosis. Reduced intensity allogeneic stem cell transplantation (RIST) was performed using a conditioning regimen comprising fludarabine 125 mg/m2 and melphalan 90 mg/m2. Hematologically complete remission and symptomatic improvement were obtained without severe transplantation-related complications. RIST may thus offer a useful treatment strategy for systemic AL amyloidosis complicated by cardiac amyloidosis.
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