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  • Title: Raloxifene: bone and cardiovascular effects.
    Author: Francucci CM, Romagni P, Boscaro M.
    Journal: J Endocrinol Invest; 2005; 28(10 Suppl):85-9. PubMed ID: 16550730.
    Abstract:
    Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal women. This SERM acts as an estrogen agonist in the skeleton, on serum lipid metabolism and on a number of coagulation factors, while it is an estrogen antagonist in the breast and uterus. Although our current data are incomplete, RLX has a favourable risk-benefit safety profile and is one of the most promising medical agents not only for the prevention of osteoporosis, but also for a large number of other disorders in post-menopausal women.
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