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  • Title: Two types of increases in free Ca2+ evoked by odor in isolated frog olfactory receptor neurons.
    Author: Sato T, Hirono J, Tonoike M, Takebayashi M.
    Journal: Neuroreport; 1991 May; 2(5):229-32. PubMed ID: 1655101.
    Abstract:
    Olfactory transduction involves second messenger-related enzymes and cAMP-gated, K+ and Ca2+ channels, which are known to be regulated by Ca2+. We report here that cytosolic free Ca2+ concentration ([Ca2+]i) in olfactory receptor neuron was increased by odorants or forskolin and Ca2+ influx contributed to the adaptation. The increases in [Ca2+]i were below two to three-fold of resting level and transient for 26 s (mean value, n = 18). The increases were due to two pathways: Ca2+ influx and release. The slow increases in [Ca2+]i by forskolin resembled those by citralva. It was suggested that the responses to citralva were accompanied by increases in intracellular cAMP and Ca2+ influx or release leading to transient increases in [Ca2+]i.
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