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  • Title: Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus.
    Author: Barker EL, Burris KD, Sanders-Bush E.
    Journal: Brain Res; 1991 Jun 28; 552(2):330-2. PubMed ID: 1655172.
    Abstract:
    A serotonin (5-HT)-mediated phosphoinositide hydrolysis response was characterized in fibroblasts cultured from rabbit choroid plexus. 5-HT elicited a maximum 8-fold increase in [3H]inositol-phosphate ([3H]IP) formation, while the partial agonists, (+)-lysergic acid diethylamide and (-)-1-(4-bromo-2,5-dimethyoxyphenyl)-2-aminopropane caused 2- and 5-fold increases, respectively. Mianserin, ketanserin, and spiperone were equipotent at blocking the 5-HT-mediated response. Thus, agonist and antagonist profiles indicate interactions with 5-HT2 receptors.
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