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  • Title: In vitro interaction of estrogen and prolactin on hormone-dependent rat mammory tumors (38511).
    Author: Lee C, Oyasu R, Chen C.
    Journal: Proc Soc Exp Biol Med; 1975 Jan; 148(1):224-6. PubMed ID: 165526.
    Abstract:
    Hormone-dependent, regressing mammary tumors in rats were incubated in a chemically defined culture medium containing tritium labeled leucine at 37 degrees for 2 hr. The rate of tritium incorporation into the protein fraction by these tissues was measured with and without the addition of 17beta-estradiol and/or ovine prolactin into the medium. Tumor tissue responded to either estrogen or porlactin by a 6-7% increase in the rate of 3-H-leucine incorporation. When the incubation medium contained both the hormones, the increase in the rate of 3-H leucine incorporation was 19% which was significantly greater than the sum of the effect of each single hormone measured independelntly. These results demonstrate a synergistic effect between estrogen and prolactin on rat mammary tumors.
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