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  • Title: Syntheses of pyridine C-nucleosides as analogues of the natural nucleosides dC and dU.
    Author: Sun Z, Ahmed S, McLaughlin LW.
    Journal: J Org Chem; 2006 Mar 31; 71(7):2922-5. PubMed ID: 16555858.
    Abstract:
    The syntheses of four pyrimidine C-nucleosides are described. These derivatives are designed as mimics of dC and dU, and in that respect, each can form two hydrogen bonds with complementary dG or dA residues. The minor groove O2 carbonyl in each derivative is replaced by a fluorine or a methyl group. The key carbon-carbon bond connecting the heterocycle to the carbohydrate is formed using a Heck-type palladium-mediated coupling reaction.
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