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  • Title: Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
    Author: Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH.
    Journal: Science; 2006 Mar 24; 311(5768):1774-5. PubMed ID: 16556844.
    Abstract:
    Autoimmune destruction of beta cells is the predominant cause of type 1 diabetes mellitus (T1DM) in humans and is modeled in non-obese diabetic (NOD) mice. Many therapeutic interventions prevent the development of T1DM in NOD mice, but few can induce its reversal once established. Intervention with Freund's complete adjuvant, semi-allogeneic splenocytes, and temporary islet transplantation has been reported to cure NOD mice of established T1DM. Using the same approach, we report here that this treatment cured 32% of NOD mice of established diabetes (>340 milligrams per deciliter blood glucose), although beta cells in these mice were not derived from donor splenocytes.
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