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  • Title: Synthesis and antimicrobial activity of N-analogous corollosporines.
    Author: Neumann H, Strübing D, Lalk M, Klaus S, Hübner S, Spannenberg A, Lindequist U, Beller M.
    Journal: Org Biomol Chem; 2006 Apr 07; 4(7):1365-75. PubMed ID: 16557326.
    Abstract:
    Corollosporine is an antimicrobial metabolite, which was isolated from the marine fungus Corollospora maritima. Owing to its basic 4-hydroxyphthalic acid anhydride structure, it has become an attractive target for a structure/activity relationship modelling of derived compounds with potential antibiotic activity. In this regard we report on the straightforward synthesis of hetero analogous corollosporines, which were easily prepared by a three-step reaction sequence, taking advantage of a novel multicomponent reaction (AAD-reaction) and a subsequent aromatization/Grignard reaction protocol. Furthermore, the obtained products were tested in several biological assays to evaluate their antimicrobial activity.
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