These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antiarrhythmogenic and antioxidant effect of the flavonoid dioclein in a model of cardiac ischemia/reperfusion.
    Author: Vianna HR, Cortes SF, Ferreira AJ, Capettini LS, Schmitt M, Almeida AP, Massensini AR, Lemos VS.
    Journal: Planta Med; 2006 Mar; 72(4):300-3. PubMed ID: 16557469.
    Abstract:
    The antiarrhythmogenic effect of the flavonoid dioclein on myocardial ischemia/reperfusion was investigated in isolated perfused rat hearts. Low concentrations of dioclein (30-300 nM) induced a reduction of arrhythmias observed during the reperfusion period. Dioclein also preserved the diastolic tension after reperfusion without affecting the systolic tension. In addition, dioclein (150 nM) dramatically reduced the formation of reactive oxygen species (ROS) observed during reperfusion in hearts. In conclusion, dioclein acts as a potent antiarrhythmogenic and antioxidant drug with an excellent protective effect during reperfusion of ischemic hearts.
    [Abstract] [Full Text] [Related] [New Search]