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  • Title: Characterization of a beta-lactamase produced by Pseudomonas paucimobilis.
    Author: Corkill JE, Hart CA, McLennan AG, Aspinall S.
    Journal: J Gen Microbiol; 1991 Jun; 137(6):1425-9. PubMed ID: 1655952.
    Abstract:
    A novel beta-lactamase enzyme produced by a strain of Pseudomonas paucimobilis is described. The enzyme differs from other recorded beta-lactamases from Gram-negative aerobic bacteria. It was constitutive, and had the characteristics of a penicillinase. One single band of beta-lactamase activity at pI 4.6 was seen on iso-electric focusing. The enzyme had a molecular mass of 30 kDa. The beta-lactamase was strongly inhibited by tazobactam, sulbactam and clavulanic acid but not by the thiol residue inhibitors p-chloromercuribenzoate and p-chloromercuriphenylsulphonic acid, or by metallo-enzyme inhibitors. Plasmid DNA was not demonstrable, suggesting that the enzyme was chromosomally encoded.
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