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  • Title: Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.
    Author: Sakurai Y, Sakurai N, Taniguchi M, Nakanishi Y, Bastow KF, Wang X, Cragg GM, Lee KH.
    Journal: J Nat Prod; 2006 Mar; 69(3):397-9. PubMed ID: 16562843.
    Abstract:
    As part of a study on potential antitumor agents from rainforest plants, two new pterocarpans, rautandiol A (1) and rautandiol B (2), together with eight known compounds, were isolated from Neorautanenia mitis. Among the compounds isolated, rotenone (3) and 12-hydroxyrotenone (4) showed significant cytotoxic activity with IC(50) values of 0.008-0.010 and 0.04-0.06 microg/mL against MCF-7 and A-549 cells, respectively.
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