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  • Title: [The importance of prostaglandins and cyclic nucleotides in the mechanism of action of the transfusion of blood and its components].
    Author: Abesadze AI, Glonti AO, Akhmeteli LI.
    Journal: Patol Fiziol Eksp Ter; 1991; (3):32-4. PubMed ID: 1656374.
    Abstract:
    The authors studied changes in the content of groups E and F2 prostaglandins (PGE and PGF2) and cyclic nucleotides (cAMP and cGMP) in blood of dogs after 20 ml/kg blood loss as well as in transfusion of whole blood, plasma and 10 ml/kg packed erythrocytes after preliminary blood letting. It was established that after loss of blood the concentration of PGE, cAMP and cGMP increases while the concentration of PGF2 in the blood reduces. It is also shown that transfusion of whole blood facilitates correction of the content of prostaglandins and cyclic nucleotides in the blood. The posthemorrhagic changes of most of the studied indices are normalized in the 24 hours after transfusion of packed erythrocytes, transfusion of plasma fails to correct the revealed shifts.
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