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  • Title: Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans.
    Author: Beyth N, Yudovin-Farber I, Bahir R, Domb AJ, Weiss EI.
    Journal: Biomaterials; 2006 Jul; 27(21):3995-4002. PubMed ID: 16564083.
    Abstract:
    The antibacterial activity of quaternary ammonium polyethylenimine (PEI) nanoparticles embedded at 1%w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (p<0.001) was found in all three types of composite resins incorporated with the synthesized nanoparticles. The effect lasted for at least 1 month. SEM demonstrated bacterial debris and no streptococcal chains at 24h of bacterial contact. The addition of 1%w/w of nanoparticles did not affect the flexural modulus and the flexural strength of the dental composite materials. The results indicate that quaternary ammonium PEI nanoparticles immobilized in resin-based materials have a strong antibacterial activity upon contact without leach-out of the nanoparticles and without compromise in mechanical properties.
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