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  • Title: Surgical pathology of the pituitary in Cushing's disease.
    Author: Saeger W.
    Journal: Pathol Res Pract; 1991 Jun; 187(5):613-6. PubMed ID: 1656411.
    Abstract:
    The frequency and the significance of the 3 main features of pituitary in Cushing's disease (ACTH secreting adenomas, ACTH cell hyperplasia, and Crooke's cells) are reported and discussed. In our most recent surgical series (1989-1990) the rate of demonstration of adenoma increased up to 96%. The frequency of paraadenomatous ACTH cell hyperplasia depends on the amount of resected tumor-free tissue. The significance of such peritumorous hyperplasia seems to be low. Crooke's cells as suppressed and transformed ACTH cells were present in each case and are a reliable indicator of a hypercortisolism.
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