These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of oxandrolone on outcome measures in the severely burned: a multicenter prospective randomized double-blind trial.
    Author: Wolf SE, Edelman LS, Kemalyan N, Donison L, Cross J, Underwood M, Spence RJ, Noppenberger D, Palmieri TL, Greenhalgh DG, Lawless M, Voigt D, Edwards P, Warner P, Kagan R, Hatfield S, Jeng J, Crean D, Hunt J, Purdue G, Burris A, Cairns B, Kessler M, Klein RL, Baker R, Yowler C, Tutulo W, Foster K, Caruso D, Hildebrand B, Benjamin W, Villarreal C, Sanford AP, Saffle J.
    Journal: J Burn Care Res; 2006; 27(2):131-9; discussion 140-1. PubMed ID: 16566555.
    Abstract:
    Severe burns induce pathophysiologic problems, among them catabolism of lean mass, leading to protracted hospitalization and prolonged recovery. Oxandrolone is an anabolic agent shown to decrease lean mass catabolism and improve wound healing in the severely burned patients. We enrolled 81 adult subjects with burns 20% to 60% TBSA in a multicenter trial testing the effects of oxandrolone on length of hospital stay. Subjects were randomized between oxandrolone 10 mg every 12 hours or placebo. The study was stopped halfway through projected enrollment because of a significant difference between groups found on planned interim analysis. We found that length of stay was shorter in the oxandrolone group (31.6 +/- 3.1 days) than placebo (43.3 +/- 5.3 days; P < .05). This difference strengthened when deaths were excluded and hospital stay was indexed to burn size (1.24 +/- 0.15 days/% TBSA burned vs 0.87 +/- 0.05 days/% TBSA burned, P < .05). We conclude that treatment using oxandrolone should be considered for use in the severely burned while hepatic transaminases are monitored.
    [Abstract] [Full Text] [Related] [New Search]