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  • Title: Effect of long-term L-threo-3,4-dihydroxyphenylserine administration on alpha 2-adrenergic receptors in platelet membranes in neurologic disorders.
    Author: Azuma T, Suzuki T, Sakoda S, Mizuno R, Tsujino S, Kobayashi T, Kishimoto S, Hiraga T, Matsubara T, Yoshida S.
    Journal: Acta Neurol Scand; 1991 Jul; 84(1):46-50. PubMed ID: 1656690.
    Abstract:
    The effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), an unnatural norepinephrine precursor, on alpha 2-adrenergic receptors in platelet membranes were investigated in a patient with familial amyloidotic polyneuropathy, two patients with multiple system atrophy, and two patients with Parkinson's disease. Each patient was treated for at least six months. While L-threo-DOPS alone, or in combination with decarboxylase inhibitor benserazide hydrochloride, produced sustained increase in plasma norepinephrine and clinical improvement, it did not induce a change in the number of alpha 2-adrenergic receptors in platelet membranes.
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