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  • Title: Primary biliary cirrhosis: when and why does the disease develop?
    Author: Floreani A, Ostuni PA, Ferrara F, Guido M.
    Journal: Dig Liver Dis; 2006 Apr; 38(4):272-5. PubMed ID: 16567309.
    Abstract:
    Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune pathogenesis, that generally develops in adult life, often in perimenopausal age. The clinical features are heterogeneous, ranging from an asymptomatic presentation to end-stage liver disease. Primary biliary cirrhosis is unknown in children and its natural history has yet to be elucidated. Following a Canadian report of primary biliary cirrhosis in two girls (16 and 15 years old), we describe a clinical case developing at 17 years of age. A temporal association between Borrelia Burgdorferi infection and diagnosis of primary biliary cirrhosis was observed.
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