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  • Title: Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.
    Author: Yoshida H, Bogaki M, Nakamura M, Yamanaka LM, Nakamura S.
    Journal: Antimicrob Agents Chemother; 1991 Aug; 35(8):1647-50. PubMed ID: 1656869.
    Abstract:
    Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that all nine type 1 mutants had a point mutation from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had a point mutation from lysine to glutamic acid at amino acid 447.
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