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  • Title: SPF-32629 A and B, novel human chymase inhibitors produced by Penicillium sp.
    Author: Shimatani T, Hosotani N, Ohnishi M, Kumagai K, Saji I.
    Journal: J Antibiot (Tokyo); 2006 Jan; 59(1):29-34. PubMed ID: 16568716.
    Abstract:
    Two new human chymase inhibitors, SPF-32629A and B, were isolated from the cultured broth of Penicillium sp. SPF-32629. These structures were determined by spectroscopic methods and identified as new pyridone compounds. SPF-32629B was the carboxylated derivative of SPF-32629A. SPF-32629A and B specifically inhibited human chymase among four serine proteases tested with the IC50 of 0.25 and 0.42 microg/ml, respectively.
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