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  • Title: Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States.
    Author: Pletz MW, Shergill AP, McGee L, Beall B, Whitney CG, Klugman KP, Active Bacterial Core Surveillance Team.
    Journal: Antimicrob Agents Chemother; 2006 Apr; 50(4):1561-3. PubMed ID: 16569885.
    Abstract:
    By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC<or=2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations.
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