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  • Title: Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.
    Author: Kirkpatrick WR, Coco BJ, Patterson TF.
    Journal: Antimicrob Agents Chemother; 2006 Apr; 50(4):1567-9. PubMed ID: 16569887.
    Abstract:
    We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.
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