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  • Title: [Determination of aristolochic acid A in Guanxinsuhe preparations by RP-HPLC].
    Author: Li L, Gao HM, Wang ZM, Wang WH.
    Journal: Zhongguo Zhong Yao Za Zhi; 2006 Jan; 31(2):122-4. PubMed ID: 16570797.
    Abstract:
    OBJECTIVE: To establish a determination method of aristolochic acid A in Guanxisuhe preparations by RP-HPLC. METHOD: The instrument used was Hewlett-Packard 1100 HPLC with a Alltech C18 column (4.6 mm x 250 mm, 5 microm). The mobile phase was methanol-water-acetic acid (68: 32:1) and the flow rate was 1.0 mL x min(-1). The UV detection wavelength was 390 nm and the column temperature was at 35 degrees C. The extracted solvent for the preparations was methanol solution contained 10% formic acid. RESULT: The calibration curve was linear (r = 0.999 9) within the range of 0.119-1.89 microg for aristolochic acid A. The average recovery 99.0%, RSD 0.63%. CONCLUSION: The method with good linear relationship was convenient, quick, accurate, and suitable for the quality control of the aristolochic acid A in Guanxinsuhe and other traditional Chinese medicines containing aristolochic acid A.
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