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  • Title: The effect of famotidine on neuromuscular transmission.
    Author: Bossa R, Chiericozzi M, Efstathiu G, Galatulas I, Ninci MA.
    Journal: In Vivo; 1991; 5(1):53-5. PubMed ID: 1657239.
    Abstract:
    We have investigated the effects of the H2 receptor antagonist famotidine on the neuromuscular transmission by using the sciatic nerve--gastrocnemius muscle preparation of rat in vitro. Famotidine, administered by I.V. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotics. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by famotidine is reversed by 4-aminopyridine but not by dimaprit. Similar results have previously been obtained with cimetidine.
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