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  • Title: HLA-E and immunobiology of pregnancy.
    Author: Tripathi P, Naik S, Agrawal S.
    Journal: Tissue Antigens; 2006 Mar; 67(3):207-13. PubMed ID: 16573557.
    Abstract:
    Recently, it has been suggested that non-classical antigens such as human leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy. In the present study, we have investigated HLA-E polymorphism in normal fertile women and recurrent spontaneous aborters to assess the effect of HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be significantly higher in patients with recurrent spontaneous abortion (chi(2) = 4.097 and P = 0.0430). Differential expression, peptide affinity, and stability of E*0101 may be one of the reasons.
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