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  • Title: Simple and rapid liquid chromatography method for determination of efavirenz in plasma.
    Author: Ramachandran G, Kumar AK, Swaminathan S, Venkatesan P, Kumaraswami V, Greenblatt DJ.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2006 May 01; 835(1-2):131-5. PubMed ID: 16574512.
    Abstract:
    A simple and rapid high performance liquid chromatographic method for determination of efavirenz in human plasma was developed. The method involved extraction of sample with ethyl acetate and analysis using a reversed-phase C(18) column (150 mm) with UV detection. The assay was linear from 0.0625 to 10.0 microg/ml. The method was specific for efavirenz estimation and the drug was stable in plasma up to one month at -20 degrees C. The average recovery of efavirenz from plasma was 101%. Due to its simplicity, the assay can be used for pharmacokinetic studies and therapeutic drug monitoring of efavirenz.
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