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  • Title: Thymosin-induced differentiation of murine thymocytes in allogeneic mixed lymphocyte cultures.
    Author: Cohen GH, Hopper JA, Goldstein AL.
    Journal: Ann N Y Acad Sci; 1975 Feb 28; 249():145-53. PubMed ID: 165764.
    Abstract:
    Calf thymosin is shown to enhance the one-way MLR of CBA thymocytes cultured with allogeneic mitomycin-C- treated C57BL/J6 spleen cells. Thymosin does not enhance the one-way MLR of CBA thymocytes cultured with syngeneic mitomucin-C-treated spleen cells. Based on this finding we present a relatively simple, rapid and quantitative in vitro microculture hioassay for inducers of T-cell differentiation and propose that thymosin treatment, when accompanied by antigen presentation, induces the two-step maturational sequence of pre-T yields T1 yields T2.
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