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  • Title: Ki-ras activation in pancreatic carcinomas of Syrian hamsters induced by N-nitrosobis(2-hydroxypropyl)amine.
    Author: Ushijima T, Tsutsumi M, Sakai R, Ishizaka Y, Takaku F, Konishi Y, Takahashi M, Sugimura T, Nagao M.
    Journal: Jpn J Cancer Res; 1991 Sep; 82(9):965-8. PubMed ID: 1657847.
    Abstract:
    Five pancreatic carcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in Syrian golden hamsters were analyzed for activation of Ki-ras at codons 12 and 13, using the polymerase chain reaction and direct sequencing. The Ki-ras gene was shown to be activated in four of the five carcinomas, and the results were further confirmed by subcloning and sequencing. All the mutations involved a G-to-A transition at the second position of codon 12, which resulted in a change at the amino acid level from glycine to aspartic acid. This mutation is identical with that reported for pancreatic tumors of Syrian hamsters induced by N-nitrosobis(2-oxopropyl)amine.
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