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  • Title: [Effects of ionic and non-ionic roentgen-contrast media upon ex vivo hemostasis in rabbits].
    Author: Klimanova EV, Petrukhina GN, Makarov VA, Sergeev PV, Bolotova EN, Shimanovskiĭ NL.
    Journal: Eksp Klin Farmakol; 2006; 69(1):60-4. PubMed ID: 16579063.
    Abstract:
    The influence of ionic and non-ionic contrast media on the ex vivo hemostasis in rabbits was studied for ionic urografin (76 %), non-ionic ultravist-300, and non-ionic omnipaque-300 intravenously injected in medium and high doses (1.5 ml/kg and 3.0 ml/kg, respectively). Ionic urografin (1.5 ml/kg) almost did not influence the level of hemostasis ex vivo. Non-ionic contrast media (ultravist and omnipaque) in the medium diagnostic dose (1.5 ml/kg) activated the hemostasis, the effect being much more pronounced in the case of omnipaque. Dose-dependent action was observed for both ionic and non-ionic contrast media.
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