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  • Title: SPR imaging of photo-cross-linked small-molecule arrays on gold.
    Author: Kanoh N, Kyo M, Inamori K, Ando A, Asami A, Nakao A, Osada H.
    Journal: Anal Chem; 2006 Apr 01; 78(7):2226-30. PubMed ID: 16579601.
    Abstract:
    Identification of small-molecule ligands for a protein of interest can facilitate the analysis of the protein's functions in biological systems. Small-molecule microarrays have allowed for rapid detection of such ligand-protein interactions in a high-throughput manner, although a label on a protein is needed to observe these interactions. By combining SPR imaging technology with our recently developed photo-cross-linked small-molecule array platform, we developed a novel platform that allows in situ observation of interactions between photo-cross-linked small molecules on gold surfaces and nonlabeled proteins in solution. Interactions of estrogenic and androgenic substances with estrogen receptor alpha were observed using this platform.
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