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  • Title: [Allergy in general practice in Arhus County. Quality assessment of diagnosis, treatment and instructions to patients. III. Allergy testing].
    Author: Jensen JK, Jakobsen MK.
    Journal: Ugeskr Laeger; 2006 Mar 27; 168(13):1336-40. PubMed ID: 16579890.
    Abstract:
    INTRODUCTION: The aim of this study was to compare the allergy test with the skin prick test and the specific IgE by Phadiatop test to a purely clinical allergy diagnosis by an allergy specialist in adult patients previously tested in general practice. MATERIALS AND METHODS: A total of 103 patients suspected of having asthma and/or rhinitis were re-evaluated with a clinical diagnosis and the two allergy tests. Both the patient and the individual general practitioner were asked about existing allergy diagnosis. RESULTS: The two test systems showed large differences in a semiquantitative linear system with an explained variation (r2) of only 8%. In comparison to a purely clinical diagnosis, they were diagnostically equal with both tests, with an additional 15% positive reactions of which 25% were judged clinically active. Both tests resulted in about 33% false-positive tests classified as clinically inactive. In the case of a positive Phadiatop test and clinically active allergy, both the patient and the general practitioner reported identical specialist diagnoses in about 75% of cases, while in 20-50% of the cases an identical diagnosis was reported when the clinical diagnosis was qualitatively different from the result of Phadiatop. CONCLUSION: The results of the two test systems often differ, and they both detect extra positive tests, in which case they should be used in a serial manner. Both tests often result in a false-positive diagnosis, and identification of clinically relevant positive tests often requires an experienced medical evaluation.
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