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  • Title: Profiling urinary metabolites of naproxen by liquid chromatography-electrospray mass spectrometry.
    Author: Aresta A, Carbonara T, Palmisano F, Zambonin CG.
    Journal: J Pharm Biomed Anal; 2006 Jun 16; 41(4):1312-6. PubMed ID: 16581219.
    Abstract:
    Glucuronidation, an important metabolic process for the biotransformation of drugs into easily eliminable water-soluble detoxification products, can also lead to biologically active or toxic glucuronide conjugates. The present work describes a liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) approach for the characterization of naproxen and O-6-desmethylnaproxen glucuronides. The method is fast and efficient and permitted to individuate alpha and beta isomers of both naproxen and O-6-desmethylnaproxen glucuronides. The procedure could be potentially extended to the characterization of other drug metabolites.
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