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  • Title: [Curative effect of interleukin 11 on chronic idiopathic thrombocytopenic purpura].
    Author: Zhang QR, Wu DP, Chen LS, Cao RN.
    Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2006 Feb; 14(1):176-8. PubMed ID: 16584619.
    Abstract:
    The aim of this study was to investigate the circulating levels of IL-11 in the patients with chronic idiopathic thrombocytopenic purpura (CITP), and its significance, and to evaluate the curative effect of rhIL-11 on CITP. The level of IL-11 in patients with CITP was determined by ELISA before and after treatment, respectively. 1.5 mg of rhIL-11 were injected subcutaneously, once a day, continuously for 14 days as one course, treatment time 1 - 2 courses as total. The results showed that the higher blood IL-11 level was found in CITP patients than that in controls (P < 0.01) and during the course of treatment the number of platelets in peripheral blood of patients with CITP parallelled to the level of IL-11. The platelet counts were obviously increased in all CITP patients after rhIL-11 treatment. It is concluded that the serum level of IL-11 in patients is correlated to the number of platelets in patients. rhIL-11 can be used as an effective treatment for CITP.
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