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  • Title: A structural model for chorismate synthase from Mycobacterium tuberculosis in complex with coenzyme and substrate.
    Author: Fernandes CL, Breda A, Santos DS, Basso LA, Souza ON.
    Journal: Comput Biol Med; 2007 Feb; 37(2):149-58. PubMed ID: 16584721.
    Abstract:
    The enzymes of the shikimate pathway constitute an excellent target for the design of new antibacterial agents; chorismate synthase (CS) catalyzes the last step of this pathway. The prediction of Mycobacterium tuberculosis (MTB) CS three-dimensional structure and the geometric docking of the coenzyme FMN and the substrate EPSP were performed using the crystal structure of CS from Streptococcus pneumoniae as template. Energy minimization of the whole complex showed, as expected, that most of the template interactions are preserved in the MTB structure, except for HIS11, ARG139 and GLN255. However, novel interactions involving ARG111, GLY113 and SER317 were also observed.
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