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  • Title: Chronic electroconvulsive treatment counteracts cortical beta-adrenoceptor upregulation induced by morphine abstinence.
    Author: Vetulani J, Antkiewicz-Michaluk L, Michaluk J, Rokosz-Pelc A.
    Journal: Pol J Pharmacol Pharm; 1991; 43(2):89-93. PubMed ID: 1658759.
    Abstract:
    Morphine treatment (20 mg/kg for 7 consecutive days) did not affect the density of [3H]dihydroalprenolol ([3H]DHA) binding sites in the cortical membranes of the rat, but during naloxone-precipitated abstinence syndrome the density of these sites increased. Electroconvulsive treatment for 6 days, which by itself decreased the density of [3H]DHA binding sites, prevented the increase.
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